Lee Glanville is an Independent Researcher in Evolutionary Medicine, Evolutionary Neuroinflammation Specialist, originator of the Lipid Encephalisation and Mismatch Hypothesis (LEMH, 2026), and developer of P-U Medicine (Proximate and Ultimate Medicine) — a classification of clinical action that extends Tinbergen's evolutionary framework to intervention. With over 20 years of clinical experience and dual postgraduate qualifications in Biological Anthropology and Nutrition & Lifestyle Medicine, Lee works with individuals navigating complex neurological, metabolic, and psychiatric conditions through an evolutionary medicine lens.

Drawing on three disciplines — Biological Anthropology (why), Functional Medicine (how), and Clinical Nutrition (mechanism) — every client receives a genotype-informed, evidence-based protocol grounded in both evolutionary science and the latest clinical research.

Areas of Special Clinical Interest

Neuroinflammation · Neurodegeneration · APOE4 · Neurolithic Diet · Mismatch Disease · P-U Medicine

Two frameworks. One body of work.

LEMH proposes that 1.5 million years of lipid-driven dietary evolution shaped the APOE allele sequence and that the modern removal of those ancestral conditions explains the neuroinflammatory and neurodegenerative burden carried by APOE4 carriers today. P-U Medicine — Glanville's Classification — provides the clinical framework that follows: a formal distinction between interventions that act on the mechanisms of disease expression and interventions that act on the evolutionary mismatch conditions that generated vulnerability in the first place. Together they form the theoretical and clinical foundation of Lee's practice.

“My Journey”

I have been fascinated by human health and evolutionary biology ever since childhood — a curiosity that shaped my entire academic and clinical path. I hold a BSc (Hons) in Biological Anthropology and am completing an MSc in Nutrition and Lifestyle Medicine, and I am a certified Functional Medicine Practitioner through the Institute for Functional Medicine.

In 2026 I proposed the Lipid Encephalisation and Mismatch Hypothesis (LEMH) — connecting 1.5 million years of hominin dietary history to the modern neuroinflammatory disease epidemic. LEMH is deposited as a preprint at Preprints.org (MDPI, June 2026) and is in preparation for submission to Evolution, Medicine and Public Health. Alongside LEMH, I developed P-U Medicine (Proximate and Ultimate Medicine) — a classification of clinical action distinguishing interventions that target the mechanisms of disease from those that address its evolutionary origins. A PhD research programme in evolutionary medicine is in active development for 2027 entry.

My clinical niche sits at the intersection of evolutionary biology, genomics, and clinical nutrition. I explore how the dietary conditions that shaped the human brain across 1.5 million years interact — or catastrophically fail to interact — with the modern food environment, and what that means for the 28% of the population carrying APOE4.