Evolutionary Neuroinflammation Specialist
Ancient lipids. Modern brains. Clinical answers.
A root cause, evolutionary framework for those living with mismatch disease
Evidence-based nutritional, metabolic & lifestyle interventions - personalised to you
Clinical tools that reconnect ancient human biology with contemporary chronic illness
Lee Glanville is an Evolutionary Neuroinflammation Specialist and originator of the Lipid Encephalisation and Mismatch Hypothesis (LEMH, 2026) — a theoretical framework connecting APOE allele evolution, hominin encephalisation, and the dietary origins of modern neuroinflammatory disease. With over 20 years of clinical experience and dual postgraduate qualifications in Biological Anthropology and Nutrition & Lifestyle Medicine, Lee works with individuals navigating complex neurological, metabolic, and psychiatric conditions through an evolutionary precision medicine lens.
Drawing on three disciplines — Biological Anthropology (why), Functional Medicine (how), and Clinical Nutrition (mechanism) — every client receives a genotype-informed, evidence-based protocol grounded in both evolutionary science and the latest clinical research.
Areas of Special Clinical Interest
Neuroinflammation · Neurodegeneration · APOE4 · Ketogenic Metabolic Therapy · Metabolic Psychiatry · Precision Nutrition · Mismatch Disease
“My Journey”
I have been fascinated by human health and evolutionary biology ever since childhood — a curiosity that shaped my entire academic and clinical path. I hold a BSc (Hons) in Biological Anthropology and am completing an MSc in Nutrition and Lifestyle Medicine, and I am a certified Functional Medicine Practitioner through the Institute for Functional Medicine.
In 2026 I proposed the Lipid Encephalisation and Mismatch Hypothesis (LEMH) — connecting 1.5 million years of hominin dietary history to the modern neuroinflammatory disease epidemic. LEMH is in preparation for peer-reviewed publication. A PhD research programme in evolutionary paleoanthropology and genomics is proposed for 2027.
My clinical niche sits at the intersection of evolutionary biology, genomics, and clinical nutrition. I explore how the dietary conditions that shaped the human brain across 1.5 million years interact — or catastrophically fail to interact — with the modern food environment, and what that means for the 28% of the population carrying APOE4.
Dr Dan Lukaczer, Director of Medical Education at Institute for Functional Medicine, (AMFCP 2025).
